Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin
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چکیده
منابع مشابه
Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin.
The gastric aspartic proteinases (pepsin A, pepsin B, gastricsin and chymosin) are synthesized in the gastric mucosa as inactive precursors, known as zymogens. The gastric zymogens each contain a prosegment (i.e. additional residues at the N-terminus of the active enzyme) that serves to stabilize the inactive form and prevent entry of the substrate to the active site. Upon ingestion of food, ea...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1998
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3350481